Steven J. Henry
Senti logo

Cell Therapy: Preclinical development
Senti Biosciences, Inc., South San Francisco, CA
Nov 2018 - Mar 2019

Steven worked as a Scientist at Senti in South San Francisco, CA supporting a cell therapy program targeting ovarian cancer. His responsibilities were chiefly assay development including ELISAs, cell co-culture, and qPCR. He also assisted with animal necropsy and flow cytometery.

Gilead logo

HIV Antiviral Long-Acting Parenterals: Preclinical development through Phase 1 IND filing
Gilead Sciences, Inc., Foster City, CA
Oct 2016 - Apr 2018

Steven worked as a Research Scientist at Gilead in Foster City, CA. Half his time was in the lab developing custom in vitro assays for small molecule formulation screening and selection and supporting in vivo PK studies. The balance was spent as a subject matter expert stewarding the technical transfer of formulations and manufacturing processes at third party CROs and CMOs. He successfully delivered the first GMP batches of a novel long-acting injectable for on time Phase 1 studies and assisted with IND filing.

Merck logo

Hepatitis B Antiviral Long-Acting Parenterals: Preclinical development
Merck & Co., West Point, PA
May 2015 - Sep 2016

Steven worked as an Associate Scientist / Postdoctoral Fellow at Merck in West Point, PA. His preclinical research on long-acting parenterals resulted in an accepted poster presentation at the 43rd Annual Meeting of the Controlled Release Society and a manuscript currently under revision at the European Journal of Pharmaceutical Sciences.

Henry. 2015. Doctoral Work.

Immune Cell Biophysics
University of Pennsylvania, Philadelphia, PA
Aug 2009 - April 2015

Steven quantified the mechanics and associated biochemistry of motile immunologic cells. His research bridged surface science and single cell biophysics, using the method of microcontact printing to pattern biomimetic vesicles and explore how adhesivity directs neutrophil migratory phenotype, adhesion ligand density sensitivity, and force generation. Steven's graduate work was funded by a National Science Foundation Graduate Research Fellowship and resulted in multiple peer-reviewed publications and national conference podium presentations. Copies of his published dissertation and defense slides are available.

Singh Center logo

Soft Lithography Process Development
Singh Center for Nanotechnology, Philadelphia, PA
Nov 2013 - Nov 2014

Concurrent with his thesis research, Steven worked as Graduate Student Fellow at the Singh Center for Nanotechnology. Steven developed standard operating procedures related to equipment and fabrication workflows for various soft lithography applications including topographical stamps and microfluidic chambers. He assisted with a massive facility relocation by qualifying equipment before and after the move to ensure process integrity and operational continuity.

Jagota Group 2009 Image

Modeling ssDNA Stretching by AFM
Lehigh University, Bethlehem, PA
Summer 2009

This independent research project was conducted under the mentorship of Anand Jagota, PhD during the summer before Steven's graduate studies commenced at UPenn. The computational project was aimed at modeling the stochastic nature of single stranded DNA stretching by Atomic Force Microscopy. The project was Steven's hands-on introduction to statistical mechanics and the modeling of stochastic processes in MATLAB. Steven's MATLAB scripts were the basis of continued work in the Jagota lab after his departure for graduate school.

Lehigh logo

Microneedle Penetration Mechanics
Lehigh University, Bethlehem, PA
Fall 2007 - Spring 2009

This two year independent research project was conducted under the mentorship of Richard P. Vinci, PhD and Walter L. Brown, PhD. The project was an investigation into the mechanism by which a conical microneedle punctures a soft-solid as related to needle half-angle, tip sharpness, and applied load with applicability to transdermal drug delivery platforms. A poster summarizing the key experimental findings can be found here.

Wyeth logo

Manufacturing Science and Technology (MS&T)
Wyeth Pharmaceuticals, Pearl River, NY
Summer 2007

During this internship Steven worked on vaccine manufacturing development at Wyeth, a pharmaceutical company since acquired by Pfizer. Working in the pilot-scale plant, Steven assisted with 15L fermentations of multiple Streptococcus pneumoniae serotypes to validate Prevnar® critical process parameters. Additionally, he worked to improve document control efforts by templating individual serotype-specific purification, fermentation, and centrifugation batch records.

Updated 21 June 2019